The Faculty of Science and the Leiden Institute of Chemistry is looking for a PhD candidate in Virtual screening combined with chemical proteomics to globally profile new targets for antibiotics.
Antibiotic-resistant bacterial infections have directly caused more than 1.2 million deaths in 2019, making the identification of new antibiotics an important priority. Covalent inhibitors are already very successful as antibiotics and we have recently identified many new covalently ligand-able binding sites in bacteria using competitive residue-specific proteomics with 20 covalent ligands. Leiden University now aims to utilize this dataset as a starting point for a first-in-class proteome-wide covalent virtual screening campaign, where we will predict the interaction landscape of an in-house.
Salary
- Salary range from € 2.540 to € 3.245 gross per month
- Leiden University offers an attractive benefits package with additional holidays (8%) and end-of-year bonuses (8.3 %), training and career development, and sabbatical leave.
- Candidates from outside the Netherlands may be eligible for a substantial tax break.
- Their graduate school offers several PhD training courses at three levels: professional courses, skills training, and personal effectiveness.
Job Requirements
The PhD position on Proteomics to Globally Profile New Targets for Antibiotics seeks candidates with
- MSc degree in Chemistry, Life Sciences, Pharmaceutical Sciences, or similar, with a passion for computational modeling and drug discovery;
- Excellent proficiency in English;
- Wet-lab biochemical experience;
- Intermediate Python experience for the automation of simulations and their analysis;
- Other desirable skills: experience with molecular docking, further development programming skills, and experience with Linux and large-scale computing facilities.
Application Process
Applicants are to send their application to Jessica van Krimpen-Kraaijenoord, j.e.van.krimpen@lic.leidenuniv.nl including the following documents:
- A letter of motivation;
- An updated CV;
- Copy of master’s thesis or any other publication (if available);
- The (preliminary) transcripts of your MSc studies and a copy of their degree;
To apply for the PhD position on Proteomics to Globally Profile New Targets for Antibiotics, click here
Application Deadline: October 30, 2022.
For more information, visit the official site.
