Postdoc on Organic Synthesis and Computational High Throughput Drug Discovery

The Faculty of Science and the Leiden Academic Centre for Drug Research (LACDR) are looking for a postdoc on organic synthesis and computational high-throughput drug discovery.

The ultimate goal of this position is to create a high-throughput workflow for the rapid discovery of high-affinity ligands for cancer-related drug targets. This specific project aims to develop a parallel synthesis platform for the rapid preparation of hits from computational discovery workflows. They will work in close collaboration with computational chemists for the virtual screenings and with biochemists for the hit validation.


As a postdoc researcher, the candidate will:

  • Develop robust parallel synthesis protocols to enable the rapid preparation of multiple hit compounds for cancer-related drug targets in a well-plate format.
  • Propose chemical transformations amenable to combinatorial library generation
  • Participate in the development and running of the computational screening workflow.
  • Supervise PhD, MSc, and BSc students and train and support them in organic synthesis.
  • Stay abreast of developments in the field, read the literature, and participate in relevant conferences.
  • Be expected to proactively propose solutions for research problems and publish them in internationally renowned journals.


They offer a fully funded postdoctoral position in the vibrant and top edge environment of the Leiden Academic Centre for Drug Research.

  • Salary ranges from € 3.226,- to € 5.090,- gross per month for a full-time position as postdoc
  • An attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development.
  • Candidates from outside the Netherlands may be eligible for a substantial tax break.

Job Requirements

The faculty is looking for an excellent, creative, and highly motivated colleague with:

  • A Ph.D. in the field of organic synthesis, medicinal chemistry, or chemical biology.
  • Strong organic synthesis background (natural product synthesis, reaction development, multistep synthesis, etc.)
  • Experience in virtual screening, docking, and/or computational chemistry and experience in coding is an advantage.
  • Affinity for computational methodologies is crucial.
  • Ability to work independently (project design, experimental planning, problem-solving)
  • Competitive publication record
  • Excellent written and spoken English.
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Application Process

Interested applicants are welcome to apply with the following documents:

  • A motivation letter should include a description of specific research interests related to the proposed project.
  • Curriculum vitae, including a list of publications;
  • Brief past research statement (maximum of 1-2 Pages);
  • Two letters of recommendation
  • Copies of diplomas

To apply for the Postdoc on Organic Synthesis and Computational High-Throughput Drug Discoveryclick here.

Deadline: November 15, 2023.

For more information on the Postdoc on Organic Synthesis and Computational High-Throughput Drug Discovery, visit the official site.

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